Zi Shen Wan Fang regulates kynurenine metabolism to alleviate diabetes-associated cognitive impairment via activating the skeletal muscle PGC1α-PPARα signaling

Author:

Yin Qingsheng,Zhang Lin,Han Xu,Zhang Hanyu,Wang Fang,Qin Xiuping,Zhuang Pengwei,Zhang Yanjun

Publisher

Elsevier BV

Subject

Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine

Reference47 articles.

1. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression;Agudelo;Cell,2014

2. Type 2 diabetes causes skeletal muscle atrophy but does not impair resistance training-mediated myonuclear accretion and muscle mass gain in rats;Ato;Exp. Physiol.,2019

3. Muscle dysfunction in type 2 diabetes: a major threat to patient's mobility and independence;Bianchi;Acta Diabetol.,2016

4. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications;Biessels;Nat. Rev. Endocrinol.,2018

5. A distinct profile of tryptophan metabolism along the kynurenine pathway downstream of toll-like receptor activation in irritable bowel syndrome;Clarke;Front. Pharmacol.,2012

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