Withaferin A, a natural thioredoxin reductase 1 (TrxR1) inhibitor, synergistically enhances the antitumor efficacy of sorafenib through ROS-mediated ER stress and DNA damage in hepatocellular carcinoma cells

Author:

Chen Xi,Zhu Ning,Wu Yajie,Zhang Ye,Zhang Yuxuan,Jin Kaiwen,Zhou Zhiyi,Chen GuangORCID,Wang JiabingORCID

Funder

Taizhou Science and Technology Bureau

Science and Technology Plan Project of Taizhou

National Natural Science Foundation of China

Zhejiang Province Natural Science Foundation

Publisher

Elsevier BV

Subject

Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine

Reference54 articles.

1. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma;Journal of hepatology,2018

2. Synergistic antitumor effect of 5-fluorouracil and withaferin-A induces endoplasmic reticulum stress-mediated autophagy and apoptosis in colorectal cancer cells;Alnuqaydan;American journal of cancer research,2020

3. Ginkgo biloba extract in combination with sorafenib is clinically safe and tolerable in advanced hepatocellular carcinoma patients;Cai;Phytomedicine: international journal of phytotherapy and phytopharmacology,2016

4. Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells;Chen;Redox biology,2019

5. The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition;Chen;Pharmacological research,2022

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