Diterpenoid honatisine overcomes temozolomide resistance in glioblastoma by inducing mitonuclear protein imbalance through disruption of TFAM-mediated mtDNA transcription

Author:

Li Zongyang,Sai Ke,Ma Guoxu,Chen Fanfan,Xu Xudong,Chen Lei,Wang Sicen,Li Weiping,Huang Guodong,Cui PingORCID

Publisher

Elsevier BV

Subject

Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine

Reference52 articles.

1. TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts;Aasumets;Biochem Biophys Rep,2021

2. Mitochondrial nucleoid clusters protect newly synthesized mtDNA during Doxorubicin- and Ethidium Bromide-induced mitochondrial stress;Alan;Toxicol Appl Pharmacol,2016

3. The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels;Bruser;Cell Rep,2021

4. Metabolic Reprogramming in Response to Alterations of Mitochondrial DNA and Mitochondrial Dysfunction in Gastric Adenocarcinoma;Chang;Int J Mol Sci,2022

5. Chemical Composition, Anti-Breast Cancer Activity and Extraction Techniques of Ent-Abietane Diterpenoids from Euphorbia fischeriana Steud;Chen;Molecules,2022

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