Investigating the synergy of Shikonin and Valproic acid in inducing apoptosis of osteosarcoma cells via ROS-mediated EGR1 expression

Author:

Chen ZhuoORCID,Wu Feng-feng,Li Jing,Dong Jia-bao,He Hong-yi,Li Xiong-feng,Lu Qian,Zhang Wen-xuan,Shao Chang-ming,Yao Zhao-nong,Lin Nong,Ye Zhao-mingORCID,Xu Jun-tao,Li Heng-yuanORCID

Funder

Key Research and Development Program of Zhejiang Province

Publisher

Elsevier BV

Reference46 articles.

1. Anti-tumor mechanisms of valproate: a novel role for an old drug;Blaheta;Med. Res. Rev.,2002

2. Shikonin derivatives for cancer prevention and therapy;Boulos;Cancer Lett.,2019

3. Loss of E-cadherin-dependent cell-cell adhesion and the development and progression of cancer;Bruner;Cold. Spring. Harb. Perspect. Biol.,2018

4. Valproic acid-like compounds enhance and prolong the radiotherapy effect on breast cancer by activating and maintaining anti-tumor immune function;Cai;Front. Immunol.,2021

5. The early growth response gene EGR-1 behaves as a suppressor gene that is down-regulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas;Calogero;Clin. Cancer Res.,2001

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