The multicomponent phytopharmaceutical SKI306X inhibits in vitro cartilage degradation and the production of inflammatory mediators

Author:

Hartog A.,Hougee S.,Faber J.,Sanders A.,Zuurman C.,Smit H.F.,van der Kraan P.M.,Hoijer M.A.,Garssen J.

Publisher

Elsevier BV

Subject

Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine

Reference27 articles.

1. Transforming growth factor-beta causes partial inhibition of interleukin 1-stimulated cartilage degradation in vitro;Andrews;Biochem. Biophys. Res. Commun.,1989

2. Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8;Attur;Proc. Assoc. Am. Physicians,1998

3. Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression;Caron;Arthritis Rheum.,1996

4. Transforming growth factor-beta is a potent inhibitor of IL-1 induced protease activity and cartilage proteoglycan degradation;Chandrasekhar;Biochem. Biophys. Res. Commun.,1988

5. Effects of SKI 306X, a new herbal agent, on proteoglycan degradation in cartilage explant culture and collagenase-induced rabbit osteoarthritis model;Choi;Osteoarthritis Cartilage,2002

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