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Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

  • Published:2020-08 Issue: Volume:13 Page:8-15
  • ISSN:2211-3207
  • Container-title:International Journal for Parasitology: Drugs and Drug Resistance
  • language:en
  • Short-container-title:International Journal for Parasitology: Drugs and Drug Resistance

Author:

Rugel Anastasia R.,Guzman Meghan A.,Taylor Alexander B.,Chevalier Frédéric D.,Tarpley Reid S.,McHardy Stanton F.,Cao Xiaohang,Holloway Stephen P.,Anderson Timothy J.C.,Hart P. John,LoVerde Philip T.

Funder

Welch Foundation

National Institutes of Health

U.S. Department of Energy

Publisher

Elsevier BV

Subject

Pharmacology (medical),Infectious Diseases,Pharmacology,Parasitology

Reference45 articles.

1. PHENIX: a comprehensive Python-based system for macromolecular structure solution;Adams;Acta Crystallogr D Biol Crystallogr,2010

2. Structural and chemical profiling of the human cytosolic sulfotransferases;Allali-Hassani;PLoS Biol.,2007

3. The proteasome as a drug target in the metazoan pathogen, schistosoma mansoni;Bibo-Verdugo;ACS Infect. Dis.,2019

4. Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population;Chevalier;Int. J. Parasitol.,2016

5. Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment;Chevalier;PLoS Pathog.,2019

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