Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice

Author:

de Sousa Maria Cristina FerreiraORCID,Imhof Dennis,Hänggeli Kai Pascal AlexanderORCID,Choi Ryan,Hulverson Matthew A.,Arnold Samuel L.M.ORCID,Van Voorhis Wesley C.ORCID,Fan Erkang,Roberto Sánchez-Sánchez,Ortega-Mora Luis M.ORCID,Hemphill AndrewORCID

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

National Institute of Food and Agriculture

U.S. Department of Agriculture

National Institutes of Health

Publisher

Elsevier BV

Reference37 articles.

1. Rab11A-Controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis;Agop-Nersesian;PLoS Pathog.,2009

2. N-terminal fusion of a toll-like receptor 2-ligand to a Neospora caninum chimeric antigen efficiently modifies the properties of the specific immune response;Aguado-Martínez;Parasitology,2016

3. Immunization with a cocktail of antigens fused with OprI reduces Neospora caninum vertical transmission and postnatal mortality in mice;Aguado-Martínez;Vaccine,2019

4. Molecular targets of the 5-amido-carboxamide bumped kinase inhibitor BKI-1748 in Cryptosporidium parvum and HCT-8 host cells;Ajiboye;Int. J. Mol. Sci.,2024

5. Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice;Anghel;Int. J. Antimicrob. Agents,2020

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