Determination of dimethylamine and nitrite in pharmaceuticals by ion chromatography to assess the likelihood of nitrosamine formation

Author:

Hu Jingli,Christison TerriORCID,Rohrer Jeffrey

Publisher

Elsevier BV

Subject

Multidisciplinary

Reference11 articles.

1. Formation of N-nitroso compounds: chemistry, kinetics and in vivo occurrence;Mirvish;Toxicol. Appl. Pharmacol.,1975

2. Potential for the formation of N-nitrosamines during the manufacture of active pharmaceutical ingredients: an assessment of the risk posed by trace nitrite in water;Ashworth;Org. Process Res. Dev.,2020

3. Simultaneous determination of eight short-chain aliphatic amines in drug substances by HPLC with diode array detection after derivatization with halonitrobenzenes;Han;J. Separ. Sci.,2017

4. Determination of dimethylamine and triethylamine in hydrochloride salts of drug substances by headspace gas chromatography using dimethyl sulphoxide-imidazole as diluent, Indones;Gopalakrishnan;J. Pharm. Sci. Technol.,2016

5. Applications of Ion Chromatography in the Analysis of Pharmaceutical and Biological Products,2012

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