Concentration-targeted phase I trials of atevirdine mesylate in patients with HIV infection: dosage requirements and pharmacokinetic studies

Author:

Morse Gene D.,Reichman Richard C.,Fischl Margaret A.,Para Michael,Leedom John,Powderly William,Demeter Lisa M.,Resnick Lionel,Bassiakos Yiannis,Timpone Joseph,Cox Steve,Batts Donald

Publisher

Elsevier BV

Subject

Virology,Pharmacology

Reference24 articles.

1. Pharmacokinetics and bioavailability of zidovudine in humans;Blum;Am. J. Med.,1988

2. Evaluation of effects of altered gastric pH on absorption of dapsone in healthy volunteers;Breen;Antimicrob. Agents Chemother.,1994

3. Inhibition of human immunodeficiency virus type 1 replication in vitro by the bisheteroarylpiperazine atevirdine (U-87201-E) in combination with zidovudine or didanosine;Campbell;J. Infect. Dis.,1993

4. Cox, S.R., Batts, D.H., Dietz, A.J., Hanover, C.K., Peel, B.G., Elfring, G.L., 1992. A phase I multiple dose study of U-87201E, a non-nucleoside RT inhibitor in normal healthy males. VIII Int. Conf. on AIDS, Amsterdam, Netherlands, 19–24 July 1992.

5. Demeter, L.M., Resnick, L., Nawaz, T., Timpone, J.G., Batts, D., Reichman, R.C., 1993. Phenotypic and genotypic analysis of atevirdine susceptibility of HIV-1 isolates obtained from patients receiving atevirdine monotherapy in a phase I clinical trial (ACTG 187): comparison to patients receiving combination therapy with atevirdine and zidovudine. 3rd Workshop on Viral Resistance. Gaithersburg, MD, September, 1993.

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