Anti-herpesvirus activity of (1′S,2′R)-9-[[1′,2′-bis(hydroxymethyl)-cycloprop-1′-yl]methyl]guanine (A-5021) in vitro and in vivo
Author:
Publisher
Elsevier BV
Subject
Virology,Pharmacology
Reference17 articles.
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2. The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow specificity compared with the herpes simplex virus type 1 thymidine kinase;Gustafson;Antimicrob. Agents Chemother.,1998
3. Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that phosphorylates zidovudine but not ganciclovir;Gustafson;J. Virol.,2000
4. Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy;Hasegawa;Cancer Gene Ther.,2000
5. Antiherpesvirus activities of (1′S,2′R)-9-[[1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl]guanine (A-5021) in cell culture;Iwayama;Antimicrob. Agents Chemother.,1998
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