The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation

Author:

Pelletier Jean-Pierre,Mineau François,Ranger Pierre,Tardif Ginette,Martel-Pelletier Johanne

Publisher

Elsevier BV

Subject

Orthopedics and Sports Medicine,Biomedical Engineering,Rheumatology

Reference21 articles.

1. Synthesis of metalloproteases and IL-6 in human osteoarthritic synovial membrane is an IL-1 mediated process;Pelletier;J Rheumatol,1995

2. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis;Firestein;Arthritis Rheum,1994

3. The synthesis of IL-1 receptor antagonist (IL-1ra) by synovial fibroblasts is markedly increased by the cytokines TNF-alpha and IL-1;Martel-Pelletier;Biochim Biophys Acta,1993

4. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases;Farrell;Ann Rheum Dis,1992

5. Nitric oxide synthesis and its regulation by rabbit synoviocytes;Stefanovic-Racic;J Rheumatol,1994

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