Active site analysis of 17β-hydroxysteroid dehydrogenase type 1 enzyme complexes with SPROUT

Author:

Alho-Richmond Sari,Lilienkampf Annamaria,Wähälä Kristiina

Publisher

Elsevier BV

Subject

Endocrinology,Molecular Biology,Biochemistry

Reference22 articles.

1. Alho S., 2005. Enhancement of synthetic SPROUT de novo ligand design program knowledge base. SPROUT application for 17β-hydroxysteroid dehydrogenase type 1 enzyme, Academic Dissertation, University of Helsinki, Gummerus Kirjapaino Oy, Saarijärvi.

2. Crystal structure of human 17β-hydroxysteroid dehydrogenase complexed with 17β-estradiol;Azzi;Nat. Struct. Biol.,1996

3. The structure of a complex of human 17β-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors;Breton;Structure,1996

4. Pseudosymmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17β-hydroxysteroid dehydrogenase;Gangloff;FASEB,2003

5. Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20Å resolution;Ghosh;Structure,1995

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