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Physiological levels of tumstatin, a fragment of collagen IV α3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via αVβ3 integrin

  • Published:2003-06 Issue:6 Volume:3 Page:589-601
  • ISSN:1535-6108
  • Container-title:Cancer Cell
  • language:en
  • Short-container-title:Cancer Cell

Author:

Hamano Yuki,Zeisberg Michael,Sugimoto Hikaru,Lively Julie C,Maeshima Yohei,Yang Changqing,Hynes Richard O,Werb Zena,Sudhakar Akulapalli,Kalluri Raghu

Publisher

Elsevier BV

Subject

Cancer Research,Cell Biology,Oncology

Reference75 articles.

1. Quantitative trait loci influence renal disease progression in a mouse model of Alport syndrome;Andrews;Am. J. Pathol.,2002

2. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis;Bergers;Nat. Cell Biol.,2000

3. Marimastat as maintenance therapy for patients with advanced gastric cancer;Bramhall;Br. J. Cancer,2002

4. Angiogenesis in cancer and other diseases;Carmeliet;Nature,2000

5. Anti-angiogenic cues from vascular basement membrane collagen;Colorado;Cancer Res.,2000

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