Acute systemic toxicity—prospects for tiered testing strategies

Author:

Botham P.A

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference15 articles.

1. The role of prevalidation in the development, validation and acceptance of alternative methods;Curren;ATLA,1995

2. Overview of the final MEIC results: II. The in vitro/in vivo evaluation, including the selection of a practical battery of cell tests for prediction of acute lethal blood concentrations in humans;Ekwall;Tox In Vitro,1999

3. European Commission, 1997. European Commission Directive on the Classification, Packaging and Labelling of Dangerous Substances in the European Union, January, 1997. Directive 67/548/EEC; Annex V. Revision.

4. Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity. NIH Publication No. 01-4499,2001

5. Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity. NIH Publication No. 01-4500,2001

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