Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators-Reference-Cited by-同舟云学术

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Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators

Published:2011-03 Issue:3 Volume:46 Page:934-943
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Qi Jinlong,Zhang Fan,Mi Yi,Fu Yan,Xu Wen,Zhang Diqun,Wu Yibing,Du Xiaona,Jia Qingzhong,Wang Kewei,Zhang Hailin

Funder

National Natural Science Foundation of China

National Basic Research Program

National 863 project

National Science Fund for Distinguished Young Scholars of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference43 articles.

1. M-channels: neurological diseases, neuromodulation, and drug development;Cooper;Archives of Neurology,2003

2. Neuronal KCNQ potassium channels: physiology and role in disease;Jentsch;Nature Reviews Neuroscience,2000

3. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel;Wang;Science,1998

4. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family;Charlier;Nature Genetics,1998

5. A potassium channel mutation in neonatal human epilepsy;Biervert;Science,1998

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1. Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain;Pharmaceuticals;2023-01-04

2. Combinations of classical and non-classical voltage dependent potassium channel openers suppress nociceptor discharge and reverse chronic pain signs in a rat model of Gulf War illness;NeuroToxicology;2022-12

3. Effective Perturbations by Small-Molecule Modulators on Voltage-Dependent Hysteresis of Transmembrane Ionic Currents;International Journal of Molecular Sciences;2022-08-21

4. Evidence for Dual Activation of IK(M) and IK(Ca) Caused by QO-58 (5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)-1H-pyrazolol[1,5-a]pyrimidin-7-one);International Journal of Molecular Sciences;2022-06-24

5. Effective Activation of BKCa Channels by QO-40 (5-(Chloromethyl)-3-(Naphthalen-1-yl)-2-(Trifluoromethyl)Pyrazolo [1,5-a]pyrimidin-7(4H)-one), Known to Be an Opener of KCNQ2/Q3 Channels;Pharmaceuticals;2021-04-21

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