Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro-Reference-Cited by-同舟云学术

Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro

Published:2018-02 Issue: Volume:146 Page:38-46
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Honegr Jan^ORCID,Malinak David,Dolezal Rafael,Soukup Ondrej,Benkova Marketa^ORCID,Hroch Lukas,Benek Ondrej^ORCID,Janockova Jana^ORCID,Kuca Kamil,Prymula Roman

Funder

Czech Science Foundation

IT4Innovations Centre of Excellence project

European Regional Development

national budget of the Czech Republic

Czech Ministry of Education, Youth and Sports

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference39 articles.

1. The path to a successful vaccine adjuvant - 'The long and winding road';O'Hagan;Drug Discov. Today,2009

2. Toll-like receptors: critical proteins linking innate and acquired immunity;Akira;Nat. Immunol.,2001

3. Vaccine Adjuvants: Preparation Methods and Research Protocols;O'Hagan,2000

4. Targeting Toll-like receptors with small molecule agents;Wang;Chem. Soc. Rev.,2013

5. Unleashing the potential of NOD- and toll-like agonists as vaccine adjuvants;Maisonneuve;Proc. Natl. Acad. Sci. U. S. A.,2014

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation;Bioorganic Chemistry;2023-12

2. Automation of Drug Discovery through Cutting-edge In-silico Research in Pharmaceuticals: Challenges and Future Scope;Current Computer-Aided Drug Design;2023-12

3. Serine-/Cysteine-Based sp²-Iminoglycolipids as Novel TLR4 Agonists: Evaluation of Their Adjuvancy and Immunotherapeutic Properties in a Murine Model of Asthma;Journal of Medicinal Chemistry;2023-03-23

4. Identification and Molecular Mechanism of Novel Immunomodulatory Peptides from Gelatin Hydrolysates: Molecular Docking, Dynamic Simulation, and Cell Experiments;Journal of Agricultural and Food Chemistry;2023-02-07

5. Small molecule modulators of immune pattern recognition receptors;RSC Chemical Biology;2023