Structural requirements of acylated Gly- l -Ala- d -Glu analogs for activation of the innate immune receptor NOD2-Reference-Cited by-同舟云学术

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Structural requirements of acylated Gly- l -Ala- d -Glu analogs for activation of the innate immune receptor NOD2

Published:2016-06 Issue: Volume:116 Page:1-12
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Gobec Martina,Mlinarič-Raščan Irena,Dolenc Marija Sollner,Jakopin Žiga

Funder

Slovenian Research Agency

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference43 articles.

1. NOD proteins: regulators of inflammation in health and disease;Philpott;Nat. Rev. Immunol.,2014

2. NOD1 and NOD2: signaling, host defense, and inflammatory disease;Caruso;Immunity,2014

3. The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration;Nigro;Cell Host Microbe,2014

4. The Nod-like receptor (NLR) family: a tale of similarities and differences;Proell;PLoS One,2008

5. Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP;Mo;J. Biol. Chem.,2012

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1. Structure-activity relationship in NOD2 agonistic muramyl dipeptides;European Journal of Medicinal Chemistry;2024-05

2. Small molecule modulators of immune pattern recognition receptors;RSC Chemical Biology;2023

3. A Robust, Gram-Scale and High-Yield Synthesis of MDP Congeners for Activation of the NOD2 Receptor and Vaccine Adjuvantation;Synthesis;2022-12-29

4. Lipidation of NOD2 Agonists with Adamantane and Stearoyl Moieties Differentially Regulates Their In Vivo Adjuvant Activity;Pharmaceutics;2022-12-09

5. Synthesis and Immunological Evaluation of Mannosylated Desmuramyl Dipeptides Modified by Lipophilic Triazole Substituents;International Journal of Molecular Sciences;2022-08-03

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