Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3- b ][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor-Reference-Cited by-同舟云学术

Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3- b ][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor

Published:2016-06 Issue: Volume:116 Page:239-251
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Zhan Zhengsheng,Peng Xia,Liu Qiufeng,Chen Fang,Ji Yinchun,Yao Shanyan,Xi Yong,Lin Yipeng,Chen Tiantian,Xu Yechun,Ai Jing,Geng Meiyu,Duan Wenhu

Funder

National Natural Science Foundation of China

National Science & Technology

Shanghai Science and Technology Commission

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference44 articles.

1. Targeting MET in cancer: rationale and progress;Gherardi;Nat. Rev. Cancer,2012

2. Targeting the HGF/c-MET pathway in hepatocellular carcinoma;Goyal;Clin. Cancer. Res.,2013

3. Tyrosine kinase receptor indistinguishable from the c-met protein;Giordano;Nature,1989

4. Drug development of MET inhibitors: targeting oncogene addiction and expedience;Comoglio;Nat. Rev. Drug Discov.,2008

5. MET signalling: principles and functions in development, organ regeneration and cancer;Trusolino;Nat. Rev. Mol. Cell Biol.,2010

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