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Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity

  • Published:2016-06 Issue: Volume:115 Page:179-190
  • ISSN:0223-5234
  • Container-title:European Journal of Medicinal Chemistry
  • language:en
  • Short-container-title:European Journal of Medicinal Chemistry

Author:

Alonso Concepción,Fuertes María,González María,Rubiales Gloria,Tesauro Cinzia,Knudsen Birgitta R.,Palacios Francisco

Funder

Dirección General de Investigación del Ministerio de Economía, Ciencia e Innovación

Universidad del País Vasco

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference61 articles.

1. Cancer statistics, CA;Siegel;Cancer J. Clin.,2013

2. DNA Topoisomerases and Cancer;Pommier,2012

3. For recent contributions see:

4. Substituted 2-arylquinazolinones: design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerases;Khadka;Eur. J. Med. Chem.,2015

5. Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity;Majumdar;Eur. J. Med. Chem.,2015

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