Cell-penetrating conjugates of pentaglutamylated methotrexate as potential anticancer drugs against resistant tumor cells

Author:

Szabó Ildikó,Orbán Erika,Schlosser Gitta,Hudecz Ferenc,Bánóczi Zoltán

Funder

Hungarian Scientific Research Fund

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference50 articles.

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3. Interaction of folylpolyglutamates with enzymes in one-carbon metabolism;Schirch;Arch. Biochem. Biophys.,1989

4. Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates;Allegra;J. Biol.Chem.,1985

5. Polyglutamation of methotrexate. Is methotrexate a prodrug?;Chabner;J. Clin. Invest.,1985

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