Pt(IV) prodrugs containing microtubule inhibitors displayed potent antitumor activity and ability to overcome cisplatin resistance

Author:

Li Lingxue,Huang Xiaochao,Huang Rizhen,Gou ShaohuaORCID,Wang Zhimei,Wang HengshanORCID

Funder

National Natural Science Foundation of China

New Drug Creation Project of the National Science and Technology Major Foundation of China

Fundamental Research Funds for the Central Universities

Priority Academic Program Development of Jiangsu Higher Education Institutions for the construction of fundamental facilities

Scientific Research Foundation of Graduated School of Southeast University

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference41 articles.

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3. Cellular processing of platinum anticancer drugs;Wang;Nat. Rev. Drug Discov.,2005

4. Redox activation of metal-based pro-drugs as a strategy for drug delivery;Graf;Adv. Drug Deliv. Rev.,2012

5. Cisplatin: mode of cytotoxic action and molecular basis of resistance;Siddik;Oncogene,2003

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