Design and synthesis of furyl/thineyl pyrroloquinolones based on natural alkaloid perlolyrine, lead to the discovery of potent and selective PDE5 inhibitors
Author:
Funder
National Natural Science Foundation of China
Shandong Province
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference29 articles.
1. The chemical development of the commercial route to sildenafil: A case history;Dale;Org. Process Res. Dev.,2000
2. Advances in targeting cyclic nucleotide phosphodiesterases;Maurice;Nat. Rev. Drug Discov.,2014
3. Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: towards the development of new PET neuroimaging probes;Liu;Eur. J. Med. Chem.,2017
4. Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease;Fiorito;Eur. J. Med. Chem.,2013
5. PDE5 inhibitors beyond erectile dysfunction;Sandner;Int. J. Impot. Res.,2007
Cited by 18 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Advancements in Phosphodiesterase 5 Inhibitors: Unveiling Present and Future Perspectives;Pharmaceuticals;2023-09-06
2. Identification, Formation, and Occurrence of Perlolyrine: A β-Carboline Alkaloid with a Furan Moiety in Foods;Journal of Agricultural and Food Chemistry;2023-08-31
3. Active components and molecular mechanisms of Sagacious Confucius’ Pillow Elixir to treat cognitive impairment based on systems pharmacology;Aging;2023-07-30
4. Pyrazolopyrimidinone Based Selective Inhibitors of PDE5 for the Treatment of Erectile Dysfunction;Chemistry & Biodiversity;2023-03-24
5. Design, synthesis and chemoinformatic studies of new thiazolopyrimidine derivatives as potent anticancer agents via phosphodiesterase-5 inhibition and apoptotic inducing activity;Journal of Molecular Structure;2023-01
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3