Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2- a ]pyridine and quinazolin-4(3H)-one derivatives as PI3Kα inhibitors

Author:

Fan Yan-Hua,Li Wei,Liu Dan-Dan,Bai Meng-Xuan,Song Hong-Rui,Xu Yong-Nan,Lee SangKook,Zhou Zhi-Peng,Wang Jian,Ding Huai-Wei

Funder

Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference36 articles.

1. PI3K/AKT signaling pathway and cancer: an updated review;Martini;Ann. Med.,2014

2. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting;Thorpe;Nat. Rev. Cancer,2015

3. Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway;J.P.;Pharmacol. Ther.,2014

4. The PI3K/AKT pathway as a target for cancer treatment;Mayer;Annu. Rev. Med.,2016

5. Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110α (PIK3CA);Volinia;Gene Genomics,1994

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