Imidazo[1,2- a ]pyrazine, Imidazo[1,5- a ]quinoxaline and Pyrazolo[1,5- a ]quinoxaline derivatives as IKK1 and IKK2 inhibitors

Author:

Patinote Cindy,Bou Karroum NourORCID,Moarbess Georges,Deleuze-Masquefa Carine,Hadj-Kaddour Kamel,Cuq Pierre,Diab-Assaf Mona,Kassab Issam,Bonnet Pierre-AntoineORCID

Funder

Société d’Accélération du Transfert de Technologies (SATT AxLr)

Lebanese University

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference39 articles.

1. NF-кB : a key role in inflammatory diseases;Tak;J. Clin. Invest.,2001

2. Receptor proximal kinases in NF-kB signalling as potential therapeutic targets in cancer and inflammation;Verstrepen;Biochem. Pharmacol.,2014

3. Selective inhibition of E-selectin, vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression by inhibitors of I kappa B-alpha phosphorylation;Chen;J. Immunol.,1995

4. Discovery of novel and selective IKK-β serine-threonine protein kinase inhibitors. Part 1;Murata;Bioorg. Med. Chem. Lett.,2003

5. Integrating cell-signalling pathways with NF-kB and IKK function;Perkins;Nat. Rev. Mol. Cell Biol.,2007

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