Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors-Reference-Cited by-同舟云学术

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Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors

Published:2013-11 Issue: Volume:69 Page:537-553
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Denoyelle Séverine,Chen Ting,Yang Hongwei,Chen Limo,Zhang Yingzhen,Halperin José A.,Aktas Bertal H.,Chorev Michael

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference41 articles.

1. eIF4E expression in tumors: its possible role in progression of malignancies

2. Reduction of translation initiation factor 4E decreases the malignancy of ras -transformed cloned rat embryo fibroblasts

3. PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA

4. The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E 1 1Edited by D. Draper

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