Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1
Author:
Funder
Double First Class University Plan
“333 Project” of Jiangsu Province
Jiangsu Province Natural Science Foundation
Graduate Research and Innovation Projects of Jiangsu Province
Publisher
Elsevier BV
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2. The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies;Shi;J. Hematol. Oncol.,2013
3. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion;Dong;Nat. Med.,2002
4. Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): sensitivity analysis of trials in melanoma, lung and genitourinary cancers;Carbognin;PLoS One,2015
5. PD-1/PD-L pathway and autoimmunity;Okazaki;Autoimmunity,2005
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