Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors

Author:

Zhang Chi,Wang Xin,Liu Hongchun,Zhang Minmin,Geng Meiyu,Sun Liping,Shen Aijun,Zhang AoORCID

Funder

Chinese National Science Foundation

Shanghai Commission of Science and Technology

Shanghai Institute of Materia Medica

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference32 articles.

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2. Gymnastics of molecular chaperones;Mayer;Mol. Cell,2010

3. Hsp90 at the sub of protein homeostasis: emerging mechanistic insight;Taipale;Nat. Rev. Mol. Cell Biol.,2010

4. Altered Hsp90 function in cancer: a unique therapeutic opportunity;Bagatell;Mol. Cancer Ther.,2004

5. Quantitative analysis of Hsp90-client interactions reveals principles of substrate recognition;Taipale;Cell,2012

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