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Design, synthesis and biological evaluation of AZD9291 derivatives as selective and potent EGFRL858R/T790M inhibitors

  • Published:2019-02 Issue: Volume:163 Page:367-380
  • ISSN:0223-5234
  • Container-title:European Journal of Medicinal Chemistry
  • language:en
  • Short-container-title:European Journal of Medicinal Chemistry

Author:

Zhao Bingbing,Xiao Zhen,Qi JianguoORCID,Luo Rong,Lan Zhou,Zhang Yanzhuo,Hu Xiaohan,Tang Qidong,Zheng Pengwu,Xu Shan,Zhu WufuORCID

Funder

The National Natural Science Funds of China

Jiangxi Outstanding Youth Talent Support Program

Natural Science Foundation of Jiangxi, China

Jiangxi Science and Technology Normal University Innovative Research Team

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference32 articles.

1. Challenges and perspectives on the development of small-molecule EGFR inhibitors against T790M-mediated resistance in non-small-cell lung cancer;Song;J. Med. Chem.,2016

2. The discovery of receptor tyrosine kinases: targets for cancer therapy;Gschwind;Nat. Rev. Canc.,2004

3. Targeting protein kinases in central nervous system disorders;Chico;Nat. Rev. Drug Discov.,2009

4. Global cancer statistics, 2012;Torre;Ca - Cancer J. Clin.,2015

5. A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor;Ciardiello;Clin. Canc. Res.,2001
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