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Design, synthesis and preliminary biological evaluation of 5,8-dihydropteridine-6,7-diones that induce apoptosis and suppress cell migration

  • Published:2018-01 Issue: Volume:143 Page:1959-1967
  • ISSN:0223-5234
  • Container-title:European Journal of Medicinal Chemistry
  • language:en
  • Short-container-title:European Journal of Medicinal Chemistry

Author:

Geng Peng-Fei,Wang Cong-Cong,Li Zhong-Hua,Hu Xiao-Ning,Zhao Tao-Qian,Fu Dong-Jun,Zhao Bing,Yu BinORCID,Liu Hong-MinORCID

Funder

National Key Research Programs of Proteins

National Natural Science Foundation of China

Key Research Program of Henan Province

Zhengzhou University

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference19 articles.

1. A prebiotic synthesis of pterins;Marin-Yaseli;Chem. Eur. J.,2015

2. Pterin chemistry and its relationship to the molybdenum cofactor;Basu;Coord. Chem. Rev.,2011

3. Syntheis and biological activity study of some new pteridine derivatives;Amjed;Res. J. Pharm. Biol. Chem. Sci.,2015

4. Synthesis and potential antiallergic activity of new pteridinones and related compounds;Ferrand;Eur. J. Med. Chem.,1996

5. New γ-fluoromethotrexates modified in the pteridine ring: synthesis and in vitro immunosuppressive activity;Kokuryo;Eur. J. Med. Chem.,2000

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