Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-RafV600E and C-Raf kinase inhibitory activities

Author:

El-Damasy Ashraf Kareem,Lee Ju-Hyeon,Seo Seon Hee,Cho Nam-Chul,Pae Ae Nim,Keum GyochangORCID

Funder

Korea Institute of Science and Technology

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference47 articles.

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4. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma;Kimura;Cancer Res.,2003

5. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia;Yuen;Cancer Res.,2002

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