Discovery of 2-methoxy-3-phenylsulfonamino-5-(quinazolin-6-yl or quinolin-6-yl)benzamides as novel PI3K inhibitors and anticancer agents by bioisostere-Reference-Cited by-同舟云学术

Discovery of 2-methoxy-3-phenylsulfonamino-5-(quinazolin-6-yl or quinolin-6-yl)benzamides as novel PI3K inhibitors and anticancer agents by bioisostere

Published:2014-03 Issue: Volume:75 Page:96-105
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Shao Teng,Wang Juan,Chen Jian-Gang,Wang Xiao-Meng,Li Huan,Li Yi-Ping,Li Yan,Yang Guang-De,Mei Qi-Bing,Zhang San-Qi

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference24 articles.

1. Tenets of PTEN Tumor Suppression

2. Targeting the phosphoinositide 3-kinase pathway in cancer

3. Lead Optimization of N-3-Substituted 7-Morpholinotriazolopyrimidines as Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of PKI-402

4. Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound 26 (PKI-587), a Highly Efficacious Dual Inhibitor

Cited by 39 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. PI3Kδ and mTOR dual inhibitors: Design, synthesis and anticancer evaluation of 3-substituted aminomethylquinoline analogues;Bioorganic Chemistry;2024-06

2. Quinazoline-based VEGFR-2 inhibitors as potential anti-angiogenic agents: A contemporary perspective of SAR and molecular docking studies;European Journal of Medicinal Chemistry;2023-11

3. Pharmacokinetics and tissue distribution study of two novel quinazoline PI3K/mTOR dual-inhibitors, potential anticancer agents;PAK J PHARM SCI;2023

4. Synthetic Methodologies and SAR of Quinazoline Derivatives as PI3K Inhibitors;Anti-Cancer Agents in Medicinal Chemistry;2023-05

5. Medicinal Chemistry of Quinazolines as Anticancer Agents Targeting Tyrosine Kinases;Scientia Pharmaceutica;2023-03-28