6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V- Escherichia coli purine nucleoside phosphorylase

Author:

Hassan Abdalla E.A.,Abou-Elkhair Reham A.I.,Parker William B.,Allan Paula W.,Secrist John A.

Funder

National Cancer Institute

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference28 articles.

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2. Gene-directed enzyme prodrug cancer therapy;Karjoo,2014

3. Tumor-cell bystander killing in colonic-carcinoma utilizing the Escherichia coil deod gene to generate toxic purines;Sorscher;Gene Ther.,1994

4. Cell to cell contact is not required for bystander cell killing by Escherichia coli purine nucleoside phosphorylase;Hughes;J. Biol. Chem.,1998

5. Gene Therapy of Cancer: Activation of Nucleoside Prodrugs withE. coliPurine Nucleoside Phosphorylase

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