Faropenem reacts with serine and metallo-β-lactamases to give multiple products
Author:
Funder
National Institutes of Health
Wellcome Trust
Medical Research Council
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference47 articles.
1. Antibiotics and bacterial resistance in the 21st century;Fair;Perspect. Med. Chem.,2014
2. Updated functional classification of beta-lactamases;Bush;Antimicrob. Agents Chemother.,2010
3. Metallo-beta-lactamases: a class apart;Bush;Clin. Infect. Dis.,1998
4. Metallo-β-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily;Bebrone;Biochem. Pharmacol.,2007
5. A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases;Lisa;Nat. Commun.,2017
Cited by 16 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance Enzyme;2024-04-29
2. Design and Biological Evaluation of Cephalosporin Based Metallo-β-lactamase (MBL) Inhibitors#;Letters in Drug Design & Discovery;2024-04-24
3. Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes;Journal of Medicinal Chemistry;2024-02-19
4. Probing the substrate binding modes and catalytic mechanisms of BLEG-1, a promiscuous B3 metallo-β-lactamase with glyoxalase II properties;PLOS ONE;2023-09-06
5. Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products;Journal of Biological Chemistry;2023-05
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3