Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo

Author:

Liu Yi-MinORCID,Tu Huang-JuORCID,Wu Chueh-Heng,Lai Mei-JungORCID,Yu Shu-Chieh,Chao Min-Wu,Wu Yi-Wen,Teng Che-Ming,Pan Shiow-LinORCID,Liou Jing-Ping

Funder

Ministry of Science and Technology, Taiwan

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference22 articles.

1. HSP90 and the chaperoning of cancer;Whitesell;Nat. Rev. Canc.,2005

2. Inhibiting protein-protein interactions of Hsp90 as a novel approach for targeting cancer;Gupta;Eur. J. Med. Chem.,2019

3. Hsp90 inhibitor as a sensitizer of cancer cells to different therapies (review);Solárová;Int. J. Oncol.,2015

4. Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: overview and current state of the art;Mellatyar;Biomed. Pharmacother.,2018

5. erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships;Schnur;J. Med. Chem.,1995

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