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Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects

  • Published:2021-11 Issue: Volume:223 Page:113604
  • ISSN:0223-5234
  • Container-title:European Journal of Medicinal Chemistry
  • language:en
  • Short-container-title:European Journal of Medicinal Chemistry

Author:

Xu Shicheng,Guo Anping,Chen Nan-nan,Dai Wei,Yang Huan-aoyu,Xie Wenqin,Wang Mengjie,You Qi-Dong,Xu Xiao-Li

Funder

National Natural Science Foundation of China

China Pharmaceutical University

State Key Laboratory of Natural Medicines

Priority Academic Program Development of Jiangsu Higher Education Institutions

Qinglan Project of Jiangsu Province of China

Foundation Research Project of Jiangsu Province

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference49 articles.

1. HSP90 and the chaperoning of cancer;Whitesell;Nat. Rev. Canc.,2005

2. Understanding of the Hsp90 molecular chaperone reaches new heights;Vaughan;Nat. Struct. Mol. Biol.,2010

3. The cellular world according to Hsp90;Richter;Nat. Struct. Mol. Biol.,2007

4. The therapeutic target Hsp90 and cancer hallmarks;Miyata;Curr. Pharmaceut. Des.,2013

5. Molecular chaperones in protein folding and proteostasis;Hartl;Nature.,2011

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