Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents

Author:

Ullah Saif,El-Gamal Mohammed I.,El-Gamal Randa,Pelletier Julie,Sévigny Jean,Shehata Mahmoud K.,Anbar Hanan S.,Iqbal Jamshed

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference59 articles.

1. Impact of ectoenzymes on p2 and p1 receptor signaling;Kukulski;Adv. Pharmacol.,2011

2. The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance;Robson;Purinergic Signal.,2006

3. A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for monitoring of nucleotide pyrophosphatase/phosphodiesterase reactions;Iqbal;Electrophoresis,2008

4. H. Zimmermann, M. Zebisch, N. Sträter, Cellular function and molecular structure of ecto-nucleotidases, Purinergic Signal.. 8.3 (1012) 437-502.

5. Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family;Goding;Biochim. Biophys. Acta (BBA) - Mol. Basis Dis.,2003

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