Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference47 articles.
1. Substrate reduction therapy for GBA1-associated Parkinsonism: are we betting on the wrong mouse?;Sidransky;Mov. Disord.,2020
2. LRRK2 activation in idiopathic Parkinson's disease;Di Maio;Sci. Transl. Med.,2018
3. Effect of selective LRRK2 kinase inhibition on nonhuman primate lung;Fuji;Sci. Transl. Med.,2015
4. Characterization of the onset, progression, and reversibility of morphological changes in mouse lung after pharmacological inhibition of leucine-rich kinase 2 kinase activity;Bryce;J. Pharmacol. Exp. Therapeut.,2021
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