Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer-Reference-Cited by-同舟云学术

Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer

Published:2021-07 Issue: Volume:219 Page:113427
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Liu Gang,Kim Hyejin,Wang Pingyuan,Fricke Doerte R.^ORCID,Chen Haiying,Wang Tianzhi,Shen Qiang,Zhou Jia

Funder

US Department of the Army

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference41 articles.

1. Apoptosis: a review of programmed cell death;Elmore;Toxicol. Pathol.,2007

2. Apoptosis in cancer: from pathogenesis to treatment;Wong;J. Exp. Clin. Canc. Res.,2011

3. Apoptosis and molecular targeting therapy in cancer;Hassan;BioMed Res. Int.,2014

4. The BCL2 family: key mediators of the apoptotic response to targeted anticancer therapeutics;Hata;Canc. Discov.,2015

5. Apoptosis regulator BAX;Liu,2016

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges;Acta Pharmaceutica Sinica B;2024-06

2. Synthesis, molecular docking studies of formononetin derivatives as potent Bax agonists for anticancer activity;Natural Product Research;2023-11-03

3. Formation of polyfluoro-1-ethylfluorenes in the reaction of perfluoropropylbenzene with tetrafluorobenzenes in an SbF5 medium;Journal of Fluorine Chemistry;2023-10

4. Optimization of BAX trigger site activator BTSA1 with improved antitumor potency and in vitro ADMET properties;European Journal of Medicinal Chemistry;2023-02

5. Melatonin Repairs Osteoporotic Bone Defects in Iron-Overloaded Rats through PI3K/AKT/GSK-3β/P70S6k Signaling Pathway;Oxidative Medicine and Cellular Longevity;2023-01-17