Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor
Author:
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference47 articles.
1. Principles of CDK regulation;Morgan;Nature,1995
2. CYCLIN-DEPENDENT kinases: engines, clocks, and microprocessors;Morgan;Annu. Rev. Cell Dev. Biol.,1997
3. Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing;Liang;Mol. Cell Biol.,2015
4. The structure and substrate specificity of human Cdk12/Cyclin K;Bösken;Nat. Commun.,2014
5. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes;Blazek;Genes Dev.,2011
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