Design, synthesis, and biological evaluation of indazole derivatives as selective and potent FGFR4 inhibitors for the treatment of FGF19-driven hepatocellular cancer-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of indazole derivatives as selective and potent FGFR4 inhibitors for the treatment of FGF19-driven hepatocellular cancer

Published:2021-03 Issue: Volume:214 Page:113219
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Chen Xiaolu,Liu Yanan,Zhang Liting,Chen Daoxing,Dong Zhaojun,Zhao Chengguang,Liu Zhiguo,Xia Qinqin,Wu Jianzhang,Chen Yongheng,Zheng Xiaohui,Cai Yuepiao^ORCID

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference41 articles.

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4. Acquired FGFR and FGF alterations confer resistance to estrogen receptor (ER) targeted therapy in ER+ metastatic breast cancer;Mao;Clin. Canc. Res.,2020

5. Acquired on-target clinical resistance validates FGFR4 as a driver of hepatocellular carcinoma;Hatlen;Canc. Discov.,2019

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