Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis
Author:
Funder
Tehran University of Medical Sciences
Shiraz University of Medical Sciences
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference23 articles.
1. 2016 Alzheimer's disease facts and figures;A.s. Association;Alzheimer's Dementia,2016
2. Amyloid beta-peptide is produced by cultured cells during normal metabolism;Haass;Nature,1992
3. Alternative selection of β-site APP-cleaving enzyme 1 (BACE1) cleavage sites in amyloid β-protein precursor (APP) harboring protective and pathogenic mutations within the Aβ sequence;Kimura;J. Biol. Chem.,2016
4. A Greek tragedy: the growing complexity of Alzheimer amyloid precursor protein proteolysis;Andrew;J. Biol. Chem.,2016
5. Identification of human islet amyloid polypeptide as a BACE2 substrate;Rulifson;PLoS One,2016
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