Design, combinatorial synthesis and biological evaluations of novel 3-amino-1′-((1-aryl-1 H -1,2,3-triazol-5-yl)methyl)-2′-oxospiro[benzo[ a ] pyrano[2,3- c ]phenazine-1,3′-indoline]-2-carbonitrile antitumor hybrid molecules-Reference-Cited by-同舟云学术

Design, combinatorial synthesis and biological evaluations of novel 3-amino-1′-((1-aryl-1 H -1,2,3-triazol-5-yl)methyl)-2′-oxospiro[benzo[ a ] pyrano[2,3- c ]phenazine-1,3′-indoline]-2-carbonitrile antitumor hybrid molecules

Published:2017-07 Issue: Volume:135 Page:125-141
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Lu Yuanyuan,Wang Linlin,Wang Xiaobing,Xi Tao,Liao Jianmin,Wang Zhixiang,Jiang Feng

Funder

Project Program of Nature Science Foundation of Jiangsu Province of China

State Key Laboratory of Natural Medicines, China Pharmaceutical University

Fundamental Research Funds for the Central Universities

National Found for Fostering Talents of Basic Science(NFFTBS)

National College Students Innovation and Entrepreneurship Training Program

Project Program of National Nature Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institution and Qing Lan Project

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference38 articles.

1. Target-oriented and diversity-oriented organic synthesis in drug discovery;Schreiber;Science,2000

2. A planning strategy for diversity-oriented synthesis;Burke;Angew. Chem. Int. Ed.,2004

3. Convergent diversity-oriented synthesis of small-molecule hybrids;Chen;Angew. Chem. Int. Ed.,2005

4. Rational approaches, design strategies, structure activity elationship and mechanistic insights for anticancer hybrids;Nepali;Eur. J. Med. Chem.,2014

5. Hybrid molecules: the privileged scaffolds for various pharmaceuticals;Shaveta;Eur. J. Med. Chem.,2016

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of Structurally Diverse and Biologically Promising Polyheterocycles Involving Benzo[a]phenazin-5-ols;Current Organic Chemistry;2024-06

2. Electrochemical Oxidative (4 + 2) Cyclization of Anilines and o-Phenylenediamines for the Synthesis of Phenazines;Organic Letters;2024-04-28

3. Novel 4-Aryl-4H-chromene derivative displayed excellent in vivo anti-glioblastoma efficacy as the microtubule-targeting agent;European Journal of Medicinal Chemistry;2024-03

4. Phenazines and Photoactive Formulations: Promising Photodrugs for Photodynamic Therapy;Dyes and Pigments - Insights and Applications;2023-11-02

5. A Simple and Efficient Method for the Synthesis of Benzo[3,4-a]Phenazin-5-Ols and Benzo[f]Pyrido[b]Quinoxalin-5-ol Derivatives Using Trisodium Citrate as an Efficient Organo-Catalyst at Room Temperature;Polycyclic Aromatic Compounds;2023-07-27