Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B

Author:

Li Xiang-Qian,Xu Qi,Luo Jiao,Wang Li-Jun,Jiang Bo,Zhang Ren-Shuai,Shi Da-Yong

Funder

National Natural Science Foundation of China

Key research and development project of Shandong province

Key Research Program of Frontier Sciences, CAS

China Postdoctoral Science Foundation

Strategic Biological Resources Service Network Programme of Chinese Academy of Sciences

NSFC-Shandong Joint Fund for Marine Science Rearch Centers

Qingdao National Laboratory for Marine Science and Technology

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference45 articles.

1. Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity;Zhang;Bioorg. Med. Chem. Lett.,2016

2. Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance;Goldstein;Curr. Drug. Targets,2001

3. A focused library of protein tyrosine phosphatase inhibitors;Comeau;J. Med. Chem.,2010

4. Protein-tyrosine phosphatase 1B is a negative regulator of insulin-and insulin-like growth factor-I-stimulated signaling;Kenner;J. Biol. Chem.,1996

5. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene;Elchebly;Science,1999

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