Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione derivatives as RAF-MEK-ERK pathway signaling pathway blockers: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships

Author:

Xie Qian,Shen Yanni,Meng Yanli,Liang Jianhui,Xu Jing,Liang Shishao,Liu Xiaoping,Wang Yan,Hu ChunORCID

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference46 articles.

1. Atypical mitogen-activated protein kinases: structure, regulation and functions;Coulomebe;Biochim. Biophys. Acta,2007

2. The Mitogen-Activated protein kinase (MAPK) pathway: role in immune evasion by trpanosomatids;Soares-Silva;Front. Microbiol.,2016

3. Trypanosoma cruzi induces cellular proliferation in the trophoblastic cell line BeWo;Droguett;Exp. Parasitol.,2017

4. Functional studies of TcRjl, a novel GTPase of Trypanosoma cruzi, reveals phenotypes related with MAPK activation during parasite differentiation and after heterologous expression in Drosophila model system;Guilherme;Biochem. Biophys. Res. Commun.,2015

5. Hepatocyte proliferation/growth arrest balance in the liver of mice during E. multilocularis infection: a coordinated 3-stage course;Zhang;PLoS One,2012

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