Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines-Reference-Cited by-同舟云学术

Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines

Published:2023-01 Issue: Volume:246 Page:114990
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Krasavin Mikhail^ORCID,Adamchik Maria,Bubyrev Andrey,Heim Christopher,Maiwald Samuel,Zhukovsky Daniil,Zhmurov Petr,Bunev Alexander,Hartmann Marcus D.

Funder

Russian Science Foundation

Max-Planck-Gesellschaft

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference35 articles.

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3. Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53;Zhou;Cell Death Dis.,2019

4. Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide;Fischer;Nature,2014

5. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins;Lu;Science,2014

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