Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors-Reference-Cited by-同舟云学术

Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors

Published:2022-12 Issue: Volume:244 Page:114856
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Dou Dou,Wang Jie,Qiao Yunjin,Wumaier Gulinuer,Sha Wenjie,Li Wenjie,Mei Wenyi,Yang Tingyuan,Zhang Chen,He Huan,Wang Caolin,Chu Linna,Sun Baihui,Su Rongrong,Ma Xiangyu,Gong Mengdie,Xie Lijuan,Jiang Wenzhe,Diao Yanyan,Zhu Lili,Zhao Zhenjiang,Chen Zhuo,Xu Yufang,Li Shengqing,Li Honglin

Funder

National Youth Science Foundation

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Fundamental Research Funds for the Central Universities

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference43 articles.

1. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries;Sung;CA Cancer J. Clin.,2021

2. EGFR mutation incidence in non-small-cell lung cancer of adenocarcinoma histology: a systematic review and global map by ethnicity (mutMapII);Midha;Am. J. Cancer Res.,2015

3. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy;Paez;Science,2004

4. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib;Lynch;N. Engl. J. Med.,2004

5. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers;Shigematsu;Jnci-J Natl Cancer I,2005

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