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Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines

  • Published:2011-12 Issue:12 Volume:46 Page:6002-6014
  • ISSN:0223-5234
  • Container-title:European Journal of Medicinal Chemistry
  • language:en
  • Short-container-title:European Journal of Medicinal Chemistry

Author:

Kaspersen Svein Jacob,Sørum Christopher,Willassen Veronica,Fuglseth Erik,Kjøbli Eli,Bjørkøy Geir,Sundby Eirik,Hoff Bård Helge

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference52 articles.

1. Second-generation epidermal growth factor tyrosine kinase inhibitors in non-small cell lung cancer;Mukherji;Expert Opin. Invest. Drugs,2009

2. Receptor tyrosine kinase inhibitors as potent weapons in war against cancers;Sharma;Curr. Pharm. Des.,2009

3. The ErbB kinase domain: structural perspectives into kinase activation and inhibition;Bose;Exp. Cell Res.,2009

4. Inhibition of angiogenesis in the treatment of non-small cell lung cancer;Keedy;Cancer Sci.,2007

5. Epidermal growth factor receptor in cancer therapy;Pedersen;Sci. Med. (Narberth, PA, U. S.),2002
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