Discovery of novel VX-809 hybrid derivatives as F508del-CFTR correctors by molecular modeling, chemical synthesis and biological assays
Author:
Funder
Fondazione Italiana Fibrosi Cistica
Italian Ministry of Health
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference46 articles.
1. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA;Riordan;Science,1989
2. Origins of cystic fibrosis lung disease;Stoltz;N. Engl. J. Med.,2015
3. Cystic fibrosis;Ratjen;Nat. Rev. Dis. Primers,2015
4. Cystic fibrosis transmembrane conductance regulator (ABCC7) structure;Hunt;Cold Spring Harb. Perspect. Med.,2013
5. Impact of the F508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure;Lewis;J. Biol. Chem.,2005
Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Computational Exploration of Potential CFTR Binding Sites for Type I Corrector Drugs;Biochemistry;2023-07-12
2. Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors;International Journal of Molecular Sciences;2023-05-27
3. Virtual Drug Repositioning as a Tool to Identify Natural Small Molecules That Synergize with Lumacaftor in F508del-CFTR Binding and Rescuing;International Journal of Molecular Sciences;2022-10-14
4. Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays;Pharmaceuticals;2022-02-23
5. Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators;Pharmaceuticals;2021-12-12
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3