Structurally novel PI3Kδ/γ dual inhibitors characterized by a seven-membered spirocyclic spacer: The SARs investigation and PK evaluation-Reference-Cited by-同舟云学术

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Structurally novel PI3Kδ/γ dual inhibitors characterized by a seven-membered spirocyclic spacer: The SARs investigation and PK evaluation

Published:2020-04 Issue: Volume:191 Page:112143
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Tao Qiangqiang,Chen Yuqing,Liang Xiao,Hu Yongzhou,Li Jiaming,Fang Fang,Wang Huchuan,Meng Chang,Liang Jingtai,Ma Xiaodong,Gui Shuangying

Funder

Natural Science Foundation of Anhui Province

Key Project of Natural Science Research in Universities of Anhui Province

University-Enterprise Cooperative Projects

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference35 articles.

1. Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo;Liu;Blood,2007

2. Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K;Okkenhaug;Trends Immunol.,2007

3. A phase 1 study of the PI3Kdelta inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL);Kahl;Blood,2014

4. The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras;Jimenez;J. Biol. Chem.,2002

5. PI3 kinase delta is a key regulator of synoviocyte function in rheumatoid arthritis;Bartok;Am. J. Pathol.,2012

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