Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy

Author:

Thompson Andrew M.ORCID,O’Connor Patrick D.,Marshall Andrew J.ORCID,Francisco Amanda F.ORCID,Kelly John M.,Riley Jennifer,Read Kevin D.,Perez Catherine J.,Cornwall ScottORCID,Thompson R.C. Andrew,Keenan Martine,White Karen L.ORCID,Charman Susan A.ORCID,Zulfiqar Bilal,Sykes Melissa L.,Avery Vicky M.,Chatelain EricORCID,Denny William A.ORCID

Funder

Department for International Development

Federal Ministry of Education and Research

Directorate-General for International Cooperation

Ministry of Foreign and European Affairs

Swiss Agency for Development and Cooperation

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference51 articles.

1. World Health Organization, Chagas disease (also known as American trypanosomiasis), Available at: https://www.who.int/news-room/fact-sheets/detail/chagas-disease-(american-trypanosomiasis) and https://www.who.int/chagas/epidemiology/en/(accessed 8 April, 2020).Crossref Partial Au1 ATL

2. Chagas disease in the 21st Century: a public health success or an emerging threat?;Bonney;Parasite,2014

3. Chagas disease: from discovery to a worldwide health problem;Lidani;Front. Public Health,2019

4. Chagas disease drug discovery: toward a new era;Chatelain;J. Biomol. Screen,2015

5. Chagas disease: review of needs, neglect, and obstacles to treatment access in Latin America;Pinheiro;Rev. Soc. Bras. Med. Trop.,2017

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